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COURSES
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Zu den Online-Skripten: Diagnostik, Epidemiologie
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Evolutionary ecology of infectious diseases: Current topics
Topic of this year (Fall 2011): Evolutionary ecology of pathogen effectors involved in innate immunity
In this course, we will consider the role of pathogen effectors in the innate immunity of plants, animals and insects. The course will be structured as indicated in the table shown below. A pdf list of the papers that will be reviewed during the semester can be downloaded here. Please click on the links shown in the table below to download each paper.
SCHEDULE FOR THE COURSE:
| Date |
Topic |
Paper(s) |
Presenting students |
Summary and Slides |
|
September 20 |
Introduction |
Overview of course organization and primary topics of interest |
McDonald |
Lecture notes |
|
September 27 |
Common and contrasting themes of plant and animal diseases |
Staskawicz; Science 2001 |
Thaddäus Perrot |
Lecture notes |
|
October 4 |
The plant immune system |
Jones; Nature 2006 |
Manuel Kradolfer |
Lecture notes |
|
October 11 |
Pathogen recogniton and innate immunity |
Akira; Cell 2006 |
Harris Héritier |
Lecture notes |
|
October 18 |
Evolution of the type III secretion system and its effectors in plant-microbe interactions |
McCann; New Phytologist 2008 |
Raphael Sieber |
Lecture notes Slides |
|
October 25 |
Evolutionary dynamics of human toll-like receptors and their different contributions to host defence |
Barreiro; PLos Genetics 2009 |
Rebecca Gau |
Slides |
|
November 1 |
Host-parasite coevolutionary conflict between Arabidopsis and downy mildew |
Allen; Science 2004 |
Louis du Plessis |
Lecture notes Slides |
|
November 8 |
Dynamic evolution of the innate immune system in Drosophila |
Sackton; Nature Genetics 2007 |
Ethan Stewart |
Lecture notes |
|
November 15 |
Host-specific toxins: effectors of necrotrophic pathogenicity |
Friesen; CellMicro 2008 |
Francesca Dennert |
Lecture notes Slides |
|
November 22 |
Population genetics of fungal and oomycete effectors involved in gene-for-gene interactions |
Stukenbrock; MPMI 2009 |
Adriano Venturini |
Lecture notes |
|
November 29 |
Direct protein interaction underlies gene-for-gene specificity and coevolution of the flax resistance genes and flax rust avirulence genes |
Dodds; PNAS 2006 |
Megan McDonald |
Slides |
|
December 6 |
Diversity and evolution of effector loci in natural populations of the plant pathogen Melampsora lini |
Barrett; Mol.Biol.Evol. 2009 |
Mark Lendenmann |
Slides |
|
December 13 |
Life history determines genetic structure and evolutionary potential of host-parasite interactions |
Barrett; TREE 2008 |
Tryggvi Stefansson |
Slides |
|
December 20 |
Concluding Discussion |
Slides |
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